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KMID : 0895420000100020124
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Journal of Korean Society of Occupational and Enviromental Hygiene
2000 Volume.10 No. 2 p.124 ~ p.139
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Biological monitoring of dye manufacturing workers by hemoglobin adducts
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Abstract
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This study was performed to investigate monoacetylbenzidine(MABZ) and benzidine(BZ) hemoglobin adducts among workers who worked at benzidine based dye manufacturing company, and exposed by benzidine and benzidine based dye. The hemoglobin adducts were compared with work environment assessment result far evaluating the usefulness of biological monitoring
The mean BZ hemoglobin adducts among the first synthesis worker´s hemoglobin adducts were 40.69 ㎍BZ/g Hb and those of dry and packing workers were 22.14 ㎍BZ/g Hb. The mean of MABZ hemoglobin adducts among 1st synthesis workers were 255.84 ㎍MABZ/g Hb, dispersion worker´s hemoglobin adducts were 76.17 ㎍MABZ/g Hb and synthesis worker´s hemoglobin adducts were 28.66㎍MABZ/g Hb. Work environment assessment results during past 3 years were 0.0065 ㎎/㎥ and 0.5659 ㎎/㎥ of benzidine based dye concentration in ambient air of drying and packing only.
Dye producing process was categorized by the possibility of exposure to benzidne and benzidine based dye. BZ and MABZ hemoglobin adducts were 19.55 ㎍BZ/g Hb, 119.80 ㎍MABZ/g Hb among workers who exposed by benzidine dihydrochloride and 16.32 ㎍BZ/g Hb, 316.56 ㎍MABZ/g Hb among workers who exposed by benzidine based dye. BZ hemoglobin adducts were not detected among control grope and MABZ hemoglobin adducts were 5.33 ㎍MABZ/g Hb. The differences between control and other exposed group was statistically significant. But there was no statistically significant differences between benzidine dihydrochloride exposed process and benzidine based dye exposed group.
BZ and MABZ hemoglobin adducts were 2.23 ㎍BZ/g Hb, 76.17 ㎍MABZ/g Hb and 3.46 ㎍BZ/g Hb, 21.33 ㎍MABZ/g Hb. So hemoglobin adducts of MABZ were 5∼0 time higher than those of BZ(P$lt;0.003).
Above results indicate that work environment assessment didn´t detected benzidine and benzidine based dye in ambient air but biological monitoring detected those of hemoglobin adducts.
Two group´s hemoglobin adducts exposed benzidine dihydrochloride and benzidine based dye were high level but wasn´t statistically significant and those were not detected in control group.
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